McKesson Clinical Reference Systems: Women's Health Advisor 2002.2
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Pyelonephritis

What is pyelonephritis?

Pyelonephritis is a bacterial infection of the kidney. It can be serious because of the important function of the kidneys and because the infection may enter the bloodstream. It can also cause pregnant women to go into labor too early (premature labor).

Kidney infections are much more common in women than men.

How does it occur?

Most kidney infections result from lower urinary tract infections, usually bladder infections.

Bacteria can travel from the vagina or rectal area (anus) into the urethra and bladder. The urethra is the tube that empties urine from the bladder. A woman's urethra is short, about 2 inches long, and is just above the vagina. Because of the location and short length of the female urethra, women are more likely to have bladder infections than men.

Lower urinary system infections may spread to the kidneys, causing pyelonephritis. When you have a bladder infection, the usual mechanism that prevents urine from flowing back to the kidneys does not work properly. This problem can allow infected urine to move into the kidneys.

The urinary system is a common site of birth defects. If your urinary system is abnormal, you have a greater risk that a bladder infection will spread to the kidneys.

If you have blockage from a kidney stone, you are at risk of developing pyelonephritis.

What are the symptoms?

The symptoms range from mild to severe. They may include:

  • fever
  • chills
  • sweats
  • abdominal pain
  • back pain
  • loss of appetite
  • nausea
  • vomiting
  • problems with urination, such as pain when you urinate or having a frequent urge to urinate.

Sometimes it is difficult to know whether urinary symptoms are caused by an infection of the lower urinary tract (for example, the bladder) or by a kidney infection. In either case, these symptoms should not be ignored. If you have these symptoms, see your health care provider immediately. Even a simple bladder infection can rapidly progress to pyelonephritis and infection in the bloodstream. Do not allow the symptoms to continue for several days before you seek treatment.

How is it diagnosed?

Your health care provider reviews your medical history, looking especially for current or recent lower urinary tract infection. You will also have a physical exam, especially to check for pain in the kidney area. A sample of your urine is tested in the lab.

How is it treated?

Antibiotics are the main treatment for a kidney infection. Your health care provider may treat you first as an outpatient. You may continue to be treated at home if you show a good response to the antibiotic after 24 hours. If you are more seriously ill or dehydrated or not responding to the antibiotic, you may need to stay in the hospital. You can be given IV medication and fluids in the hospital.

You will need to take antibiotics for at least 10 days. All bacteria must be killed to prevent kidney damage and to keep the infection from returning.

Your antibiotic may need to be changed after the first day or two of treatment if lab tests of the bacteria in your urine show a different antibiotic will work better. Your health care provider will call you if this is the case.

How long do the symptoms last?

How long it takes you to recover depends on how severe your symptoms are when you start treatment. In mild cases, symptoms lessen in the first 1 to 2 days. More severe cases require several days before you begin to feel better.

With proper treatment there are few complications of pyelonephritis. If your symptoms return soon after you finish your treatment, further tests may be necessary. Your health care provider will determine whether an underlying cause is present, such as a kidney stone.

How can I take care of myself?

  • Notice whether your symptoms lessen once you start taking the antibiotic.
  • Drink a lot of fluids.
  • Take all your medicine according to your health care provider's instructions, even when you begin to feel better.
  • Promptly report worsening or recurrent symptoms to your health care provider .

What can be done to help prevent pyelonephritis?

Most cases of pyelonephritis in women result from bladder infections. The best way to prevent kidney infections is to try to prevent bladder infections. Ways women can try to prevent these infections are:

  • Drink plenty of water and other noncaffeinated drinks. (Caffeine can cause the body to lose fluids.)
  • Avoid contaminating the urethra with bacteria from the anal area by practicing good hygiene when you use the toilet (for example, you should wipe from front to back).
  • Avoid using irritating cosmetics or chemicals in the area of the vagina and urethra (such as scented napkins or panty liners).
  • Urinate after you have sexual intercourse.

Developed by McKesson Clinical Reference Systems.
Published by McKesson Clinical Reference Systems.

This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.

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